Effectiveness of cholesterol lowering medicine

Cholesterol lowering drugs have attracted considerable attention in recent times. This is because of their potential to prevent cardiovascular disease by delaying the accelerated atherosclerosis in patients who have a high cholesterol level. Several drugs used to lower the plasma level of cholesterol. Drugs lower basic level low-density lipoprotein (LDL) because raised LDL is associated with atherosclerosis. On the other hand, high-density lipoprotein (HDL) increased because it is protective against atherosclerosis.

Some error in cholesterol metabolism leading to a number of diseases, cholesterol levels are high. Such groups of diseases known as primary hyperlipoproteinemias. Cholesterol lowering drugs used to treat these conditions.

High cholesterol level is a risk factor for cardiovascular disease. The decision to prescribe drugs depends not only on LDL cholesterol level, but also on associated Coronary Artery Disease (CAD) risk factors such as diabetes mellitus, hypertension, obesity, etc. All topics should be given drug therapy, if LDL cholesterol level is more than 190 mg/dl. Drugs recommended for those with existing coronary heart disease, even at 100 mg/dl.

Statins are leading cholesterol lowering medicine

Statins or HMG ROUNDS-COA reducatse inhibitors are the most frequent drugs used to lower cholesterol levels. These drugs are tolerated much and is very effective. They inhibit HMG ROUNDS-COA reductase, which is an important enzyme in the metabolism of cholesterol. Therapeutic doses reduce cholesterol synthesis by 20-50%. The commonly used statins are pravastatin, fluvastatin, lovastatin as atorvastatin, simvastatin. Various statins differ in their strength and maximum efficiency in reducing LDL cholesterol. The enzyme, HMG ROUNDS-COA reductase, which is hampered by these drugs has maximum activity towards midnight. This is why all statins are administered at bedtime to achieve maximum efficiency.

Statins are usually well tolerated. But there may be some side effects like headache, bowel break, nausea, rashes. Sleep disorders have also been reported. Muscle soreness in not a common side effect. Statins are the first-choice drugs to lower cholesterol levels. They are also the first-choice drugs to lower cholesterol levels in diabetics.

Common cholesterol lowering medicine

Bile acid complexing agents: or resins are another group of drugs used in lowering cholesterol levels. Commonly used resins, cholestyramine, colestipol. These drugs bind bile acids in the intestine. Bile acids bound to drugs is lost in the stool and the depletion of the bile acid pool stimulates the conversion of cholesterol to bile acid, the result is a decrease in cholesterol levels. About half of patients who take cholestyramine experience constipation and some complaints anorexia, abdominal, and occasional diarrhea.

Nicotinic Acid is also used to lower plasma triglyceride and cholesterol levels and increase HDL cholesterol. Flushing of the skin and stomach upset commonly occur.

Another class of drugs used to lower cholesterol level is Fibric acid derivatives. The activate lipoprotein lipase, which is a key enzyme in the degradation of very low density lipoprotein (VLDL) results in lowering circulating triglycerides. Drugs are, clofibrate, gemfibrozil, bezafibrate, etc. Common side effects are loose motions, skin rashes, body ache and headache. Some other drugs that lower cholesterol levels and Probucol Gugulipid also.

These drugs help to lower cholesterol levels. However, lifestyle changes such as low fat, low cholesterol diet, regular exercise, smoking cessation, etc. should be followed in order to reduce the level of cholesterol. This should be the primary approach on drugs used or not.

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